For Sponsors & CROs
One counterparty. Committed capacity. Owner-investigator alignment.
Vellum SMO offers sponsors and CROs a single, accountable site network — one point of accountability, one relationship lead, and a physician base that has a personal stake in your study’s success.
One counterparty. Committed capacity. Owner-investigator alignment.
Vellum SMO offers sponsors and CROs a single, accountable site network — one coordinated engagement structure, one relationship lead, and a physician base that has a personal stake in your study’s success.
The Constraint
The bottleneck was never the patients
Eligible patients are rarely the constraint the industry treats them as. Across most indications, the true, structurally fixed bottleneck is the supply of providers and practices committed enough to run a study well.
Only 4% of U.S. healthcare providers ever conduct clinical research. Half of all principal investigators run a single study and never return. More sponsor funding does not expand this pool — it bids up access to the same finite supply.
The Network
The capacity you’d be working with
15
Dedicated Research Sites
+10
Referral Network Sites
200+
Affiliated Raters & NPs
~90,000
Combined Active Patient Panel
40+ States
Reached by the affiliated network
70%+
Panel Identifies as Racial/Ethnic Minority
25+ yrs
Average experience of Vellum’s site management leadership
Vellum’s hub-and-spoke design routes eligible patients from 10 referral-network practices into 15 dedicated, coordinator-staffed research sites. Practice ownership, billing, EMR, and clinical autonomy remain entirely with each site — Vellum manages research operations centrally.
The Model
Built differently from the start
Owner-investigators, not subcontractors
Participating physicians hold a direct ownership stake in Vellum’s performance. Enrollment success is not incidental — it is personal. This is a structurally different incentive than a per-visit fee.
One counterparty
Every site operates under Vellum’s unified SOPs, systems, and clinical management. One coordinated engagement structure supports the network. One senior relationship lead handles your studies. No site-by-site coordination, no fragmented accountability.
AI-native operations
AI-assisted site activation, scheduling, documentation, and sponsor communication. Centralized electronic systems across the full network provide real-time data visibility and reduce query burden from first patient in.
For CROs
Reserved capacity for a matched pipeline
Vellum offers CROs a preferred-provider partnership structure: a reserved block of dedicated site capacity in exchange for a matched pipeline of study opportunities. Reserved capacity means real-time feasibility confidence — not a shared-market estimate your competitors can also cite.
Faster feasibility responses
Reserved capacity and network data available ahead of RFP, not assembled post-award.
A differentiated proposal
Preferred-provider access to owner-investigator sites is a line no open-market competitor can write into the same bid.
Priority placement
Your studies are placed before Vellum entertains other inquiries for that capacity.
Therapeutic Areas
Depth across the indications you’re recruiting for
CNS & Behavioral Health
Depression, including treatment-resistant depression · Anxiety disorders and anxious depression · OCD, PTSD, and trauma-related conditions · Adult ADHD · Opioid and substance use disorder · Child, adolescent, adult, and veteran populations.
Differentiating capability: In-house interventional psychiatry — TMS, ketamine infusion, esketamine, neurofeedback, and EMDR.
Cardiometabolic & Primary Care
Type 2 diabetes and metabolic disease · Hypertension and stroke-risk management · Cardiac disease · Peripheral vascular disease · Obesity and medical weight management · Joint pain and arthritis.
Differentiating capability: Broad, same-day-access primary care population providing direct reach into the highest-demand cardiometabolic categories.
Oncology
Solid tumors and hematologic malignancies · Phase 2 and Phase 3 interventional studies · Independent community oncology and hematology-oncology practices
Network expansion: Vellum is actively partnering with independent community oncology practices, extending the same single-counterparty contracting, unified quality systems, and dedicated site operations to oncology research.
Next Steps
How we get started
1
Mutual NDA & introductory call
Align on therapeutic-area fit, timelines, and confidentiality.
2
Capacity & partnership feasibility review
Vellum confirms available capacity and assesses fit against your pipeline profile and study requirements.
From there, we move at the pace that works for both parties.
For Sponsors & CROs
One counterparty. Committed capacity. Owner-investigator alignment.
Vellum SMO offers sponsors and CROs a single, accountable site network — one point of accountability, one relationship lead, and a physician base that has a personal stake in your study’s success.
The Constraint
The bottleneck was never the patients
Eligible patients are rarely the constraint the industry treats them as. Across most indications, the true, structurally fixed bottleneck is the supply of providers and practices committed enough to run a study well.
Provider commitment
Only 4% of U.S. healthcare providers ever conduct clinical research. Half of all principal investigators run a single study and never return. More sponsor funding does not expand this pool — it bids up access to the same finite supply.
Network quality
Vellum brings committed specialist practices together under a unified operational and accountability model.
Study readiness
Dedicated research infrastructure supports reliable activation, enrollment, and execution.
A single relationship
One accountable counterparty coordinates the network for sponsors and CROs.
The Model
Built differently from the start
Owner-investigators, not subcontractors
Participating physicians hold a direct ownership stake in Vellum’s performance. Enrollment success is not incidental — it is personal. This is a structurally different incentive than a per-visit fee.
One counterparty
Every site operates under Vellum’s unified SOPs, systems, and clinical management. One point of accountability covers the network. One senior relationship lead handles your studies.
AI-native operations
AI-assisted site activation, scheduling, documentation, and sponsor communication. Centralized electronic systems across the full network provide real-time data visibility from first participant in.