For Practices
Research capability built around your practice.
Vellum SMO partners with independent physician practices to activate clinical research programs without disrupting clinical operations, payer relationships, or practice ownership. We build the infrastructure — you provide the physician and dedicated clinical capacity.
For Practices
Research capability built around your practice
Vellum SMO partners with independent physician practices to activate clinical research programs without disrupting clinical operations, payer relationships, or practice ownership. We build the infrastructure — you provide the physician and dedicated clinical capacity.
The Opportunity
Where clinical research is heading
Sponsors and CROs have shifted significant clinical research activity toward community specialist practices — sites that carry established physician relationships, specialty depth, and procedural breadth. What they need is consistent quality at scale: one compliance framework and one accountability relationship across a network of sites. Independent specialist practices have what sponsors are looking for. What most lack is the infrastructure to participate on sponsor terms — trained coordinators, regulatory systems, IRB relationships, and an established track record. Vellum provides all of it.
Our Model
What partnership with Vellum looks like
We build the infrastructure
Vellum manages site activation, regulatory documentation, IRB coordination, sponsor contracting, GCP training, and study coordinator deployment. Your practice does not absorb administrative overhead.
You place qualified investigators
Participating physicians serve as Principal Investigators on studies placed at your site. That work is compensated directly from sponsors — separate from and in addition to your clinical revenue.
We share in the outcome
Independent physician practices participate in Vellum’s network research revenue on a quarterly basis, and in the value the platform creates over time. This is a partnership structure, not a vendor relationship.
The Regulatory Reality
What running a compliant trial actually requires
ICH E6(R3) Good Clinical Practice sets mandatory requirements for every site that participates in a sponsor-funded study. Sponsors will not award studies to sites that cannot demonstrate them.
GCP certification
Every physician and staff member who touches a study must hold current GCP certification before first contact with any study participant. Renewed every three years. Non-negotiable.
A dedicated study coordinator
A full-time, trained Clinical Research Coordinator responsible for source documentation, scheduling, data entry, regulatory filing, and monitor visits. Cannot be shared with clinical staff.
IRB and regulatory infrastructure
IRB submissions, protocol amendments, ongoing compliance, and an audit-ready Investigator Site File maintained at all times.
Sponsor credibility
Sponsors run site qualification visits and review prior performance before awarding any study. An unproven site without established relationships does not get studies.
Vellum brings all four on day one — a GCP-certified team, an experienced coordinator placed and managed by Vellum, full IRB and regulatory infrastructure, and an established sponsor network.
For Practices
Three ways your practice benefits
01. Direct investigator compensation
Physicians and licensed clinical staff earn professional fees on every study placed at your site — paid from sponsors through Vellum as sponsor pass-through compensation. Compensation varies by therapeutic area, phase, and role.
02. Quarterly network distributions
Participating practices receive a share of Vellum SMO’s net research revenue each quarter, weighted by your site’s overall research contribution.
03. Long-term value participation
Practices hold an ownership interest in the Vellum network. As the platform grows, participating practices share in that outcome.
What Stays Yours
Your clinical practice is untouched
STAYS WITH YOUR PRACTICE
- Ownership of your practice entity
- Clinical billing and payer contracts
- EMR and all clinical records
- Your clinical staff
- Facility and equipment
- Malpractice coverage on clinical work
- Clinical schedule and clinical autonomy
- Physician-patient relationships
VELLUM PROVIDES
- Sponsor and CRO relationships
- Study coordinator (Vellum-employed, on-site)
- Regulatory and IRB management
- Quality management and audit readiness
- GCP training and certification
- Sponsor contracting and management
- Scheduling and documentation technology
- Clinical research infrastructure from day one
You’re joining a network, not a vendor list
Vellum’s hub-and-spoke model connects 15 dedicated research sites with 10 referral-network practices across a 40+ state U.S. footprint. Referral-network practices route eligible participants to the nearest dedicated research site — widening the referral network for every study without adding activation complexity to the referral practice.
Next Steps
Find out if your practice is a fit
Vellum works across CNS and behavioral health, cardiometabolic and primary care, and oncology. We are selective about the sites we activate and the studies we place. If you are interested in exploring research participation, get in touch.
The Opportunity
Where clinical research is heading.
Sponsors and CROs have shifted significant clinical research activity toward community specialist practices — sites that carry established physician relationships, specialty depth, and procedural breadth.
What they need is consistent quality at scale: one compliance framework and one accountability relationship across a network of sites.
Independent specialist practices have what sponsors are looking for.
Vellum SMO
What most lack is the infrastructure to participate on sponsor terms — trained coordinators, regulatory systems, IRB relationships, and an established track record. Vellum provides all of it.
Our Model
What partnership with Vellum looks like.
We build the infrastructure.
Vellum manages site activation, regulatory documentation, IRB coordination, sponsor contracting, GCP training, and study coordinator deployment. Your practice does not absorb administrative overhead.
You place qualified investigators.
Participating physicians serve as Principal Investigators on studies placed at your site. That work is compensated directly from sponsors — separate from and in addition to your clinical revenue.
We share in the outcome.
Independent physician practices participate in Vellum’s network research revenue on a quarterly basis, and in the value the platform creates over time. This is a partnership structure, not a vendor relationship.
The Regulatory Reality
What running a compliant trial actually requires.
ICH E6(R3) Good Clinical Practice sets mandatory requirements for every site that participates in a sponsor-funded study. Sponsors will not award studies to sites that cannot demonstrate them.
Requirements
Built for compliance.
Every study site must be prepared to meet sponsor and regulatory expectations from day one.
GCP certification.
Every physician and staff member who touches a study must hold current GCP certification before first contact with any study participant. Renewed every three years.
A dedicated study coordinator.
A full-time, trained Clinical Research Coordinator responsible for source documentation, scheduling, data entry, regulatory filing, and monitor visits. Cannot be shared with clinical staff.
IRB and regulatory infrastructure.
IRB submissions, protocol amendments, ongoing compliance, and an audit-ready Investigator Site File maintained at all times.
Sponsor credibility.
Sponsors run site qualification visits and review prior performance before awarding any study. An unproven site without established relationships does not get studies.
Day One
Ready from the start.
Vellum brings all four on day one — a GCP-certified team, an experienced coordinator placed and managed by Vellum, full IRB and regulatory infrastructure, and an established sponsor network.
For Practices
Three ways your practice benefits
01.
Direct investigator compensation
Physicians and licensed clinical staff earn professional fees on every study placed at your site — paid from sponsors through Vellum as sponsor pass-through compensation. Compensation varies by therapeutic area, phase, and role.
02.
Quarterly network distributions
Participating practices receive a share of Vellum SMO’s net research revenue each quarter, weighted by your site’s overall research contribution.
03.
Long-term value participation
Practices hold an ownership interest in the Vellum network. As the platform grows, participating practices share in that outcome.
What Stays Yours
Your clinical practice is untouched
Stays with your practice
• Ownership of your practice entity
• Clinical billing and payer contracts
• EMR system and patient records
• Malpractice coverage
• Clinical staff employment
• Facility lease and clinical equipment
Vellum provides everything else a clinical research program requires — so your practice can participate without taking on new operational complexity.
Find out if your practice is a fit
Vellum works across CNS and behavioral health, cardiometabolic and primary care, and oncology. We’re selective about the sites we activate and the studies we place. If you’re interested in exploring research participation, get in touch.